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"Unequivocal evidence would require a randomized controlled trial, but this would be unethical." Still, one expert noted that while the study can't prove that cannabis was the cause of bipolar disorder or depression, it adds to growing evidence that the drug is not harmless

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Maduro leaf requires an intensive process of curing and fermentation beyond the usual, with a process that includes multiple re-bundlings, high temperatures, and lots and lots of time, resulting in a leaf that is dark, thick, and dense with flavor